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Stem Cell Therapy Can Help Reverse Early-Stage Multiple Sclerosis
"This is the first time we have turned the tide on this disease," Lancet quoted principal investigator Richard Burt, M.D. chief of immunotherapy for autoimmune diseases at the Feinberg School, as saying.
It was found that the patients in the small phase I/II trial continued to improve for up to 24 months after the transplantation procedure and then stabilized.
They experienced improvements in areas in which they had been affected by multiple sclerosis including walking, ataxia, limb strength, vision and incontinence.
Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the central nervous system. In its early stages, the disease is characterized by intermittent neurological symptoms, called relapsing-remitting MS.
During this time, the person will either fully or partially recover from the symptoms experienced during the attacks.
Within 10 to 15 years after onset of the disease, most patients with this relapsing-remitting MS progress to a later stage called secondary progressive multiple sclerosis, in which they experience a steady worsening of irreversible neurological damage.
The trial recruited 21 patients between 20 to 53 years of age, who had relapsing-remitting multiple sclerosis that had not responded to at least six months of treatment with interferon beta. The patients had had MS for an average of five years.
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