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Statins Do Not Prevent Alzheimer's Disease
Statins includes medications like atorvastatin (Lipitor) and pravastatin (Pravachol), which are some of the best-selling drugs in the world.
The drugs lower cholesterol by inhibiting a key enzyme used by the body to make it, which decreases cholesterol formation and helps reduce the amount of low-density lipoprotein (LDL or "bad" cholesterol).
"From these trials, which contained very large numbers and were the gold standard ... it appears that statins given in late life to individuals at risk of vascular disease do not prevent against dementia. I feel the follow-up time was sufficient to allow for an effect to appear," said lead study author Bernadette McGuinness, a senior clinical research fellow in geriatric medicine at Queen's University in Belfast, Ireland.
Many studies have shown that elevated serum cholesterol levels may lead to AD, and thus lowering them could prevent the neurological disorder.
The review comprised 26,340 participants in two major studies.
One study, the Medical Research Council/British Heart Foundation Heart Protection Study (HPS), looked at simvastatin (Zocor) use in 20,536 patients and followed them for five years.
The other study, the PROSPER trial, looked at pravastatin use in 5,804 patients, with an average follow-up of 3.2 years.
Both studies were double-blind randomized, placebo-controlled studies of statin medications in individuals at risk for dementia and Alzheimer disease and had participants between the ages of 40 and 82 in total.
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