login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Standard Treatment for a Brain Tumor May Help Spur Cancer's Return
Glioblastoma multiforme is the most prevalent and aggressive form of primary brain tumor and is notoriously resistant to standard therapies. Dr. Eric Holland, from Memorial Sloan-Kettering Cancer Center in New York, examined the role of ABCG2, a protein linked with drug resistance, in glioma cancer stem-like cells. "ABC proteins are transporters that participate in tumor resistance by actively transporting drugs across the cell membrane, serving to protect cells from chemotherapeutic agents," offers Dr. Holland.
Dr. Holland and colleagues employed a method that allowed visualization of ABC-mediated efflux of fluorescent dye to identify and isolate "side population" (SP) cells from mouse and human glioblastomas. "Because the SP phenotype in glioma cancer stem-like cells is mainly mediated by ABCG2, as shown by the almost complete abolition of this phenotype when ABCG2 activity is blocked, we subsequently studied the oncogenic potential of ABCG2," explains Dr. Holland.
The researchers confirmed that SP cells are highly tumorigenic, have the ability to self-renew, and are resistant to chemotherapy. These results verified that ABCG2 activity, although not by itself oncogenic, is a marker for glioma stem-like cells. Further, the researchers identified a detailed molecular mechanism that modulates the activity of ABCG2 and enhances the ability of cancer stem-like cells to expel drugs.
|
|
|
More News on: Parkinsons Disease, Parkinsons Disease Surgical Treatment, Brain Tumor, Brain Tumors, Cancer, Brain, Tumor Markers For Cancer Diagnosis and Prognosis, Brain Facts, Ataxia
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
 | Quiz on Brain Feeling bad, sad, silly or glad? Find out what is responsible by taking part in our brain quiz. 
|
- News Quick Links
 |
Brain
Complete Medindia Resources
|
| News Categories: |
| » | Cardio-Pulmonary Function can be a Strong Indicator for Survival Chances of Breast Cancer Patients |
| » | Post Surgery Will the Tumour Return? New Breast Cancer Test to Predict Exactly |
| » | Scientists Develop Compound That Triggers Cancer Cell Death |
| » | Iraqi National Hopes to Find Affordable Treatment for His Cancer in India |
| » | New Technique can Help Doctors Detect Pancreatic Cancer |
| More Cancer News | |
|
