Sleep Apnea Could Increase Insulin Resistance

by Gopalan on  May 18, 2010 at 11:27 AM Diabetes News
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More evidence to show that sleep apnea is a risk factor diabetes. Intermittent hypoxia associated with sleep apnea causes a distinct drop in insulin sensitivity in mice, according to researchers from the University of Pittsburgh Medical Center.

But this alteration in insulin sensitivity doesn’t seem to occur in the case of  chronic hypoxia, such as that associated with high altitude.

Hypoxia is a pathological condition in which the body as a whole (generalized hypoxia) or a region of the body (tissue hypoxia) is deprived of adequate oxygen supply.

Sleep apnea is a sleep disorder characterized by pauses in breathing during sleep, thus disrupting oxygen supply, it may be noted.

To determine whether intermittent hypoxia (IH) and chronic hypoxia (CH) would have different metabolic effects, Dr. Lee and colleagues fitted adult male mice with arterial and venous catheters for continuous rapid blood monitoring of glucose and insulin sensitivity. They then exposed the mice to either seven hours of IH, in which treatment, oxygen levels oscillated, reaching a low of about 5 percent once a minute, or CH, in which they were exposed to oxygen at a constant rate of 10 percent, and compared each treatment group to protocol-matched controls.

When compared to the control group, the IH mice demonstrated impaired glucose tolerance and reduced insulin sensitivity; the CH group, however, showed only a reduction in glucose tolerance but not insulin sensitivity compared to controls. "Both intermittent hypoxia and continuous hypoxia exposed mice exhibited impaired glucose tolerance, but only the intermittent hypoxia exposed animals demonstrated a reduction in insulin sensitivity," said Euhan John Lee, M.D., a fellow at the Medical Center.

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