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Significant Breakthrough in Liver Cancer Treatment

February 09, 2008 at 4:45 PM Cancer News

A study led by an Indian oncologist has reported the novel discovery of both “cancer stem cells” and normal stem cells in the liver.

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The authors say that comparison between their genetic “signatures” can lead to the development of an experimental drug, thus aiding the treatment of liver cancer.

It has long been believed that up to 40 percent of liver cancer is caused by gone wild, master cells in the organ that have lost all growth control. However, until now the scientists were unable to find any kind of good or bad cancer cells in the liver.

The results of this study by Lopa Mishra, M.D., Director of Cancer Genetics in the Department of Surgery at Georgetown University and the Department of Veterans Affairs Medical Center, and the Lombardi Comprehensive Cancer Center, have indicated that use of the agent, a stat3 inhibitor, significantly inhibited liver cancers in human cancer cell lines and mice.

“After locating the cancer stem cells that help control development of these tumours, we were able to find a potential vulnerability that might form the basis of a new treatment for this disease - which is greatly needed,” said Mishra.

She said that liver (hepatocellular) cancer is one of the most lethal and prevalent cancers in the world and 5-year survival in the disease is less than 5 percent.

The results of the study come through decades of research in Mishra’s laboratory into the genetic pathways important to development of liver cancer.

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Significant Breakthrough in Liver Cancer Treatment

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