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Sex Hormones Linked With Osteoporotic Fracture in Older Men
Low levels of estradiol or high levels of sex hormone binding globulin (SHBG) are associated with an increased risk of osteoporotic fracture in older men, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The study also finds that men with low levels of testosterone combined with high levels of SHBG are also at higher risk for bone fracture.
Testosterone is the predominant male sex hormone and estradiol is a sex hormone that provides most estrogen effects in both men and women. SHBG, a protein that binds to estradiol and testosterone in the blood, is known to reduce circulating sex steroid concentrations and has also been associated with fracture risk.
Previous studies have shown that with aging, sex hormone concentrations decline and fracture rates increase. Until now, few studies have adequately assessed the nature of the association of sex hormones with bone fracture risk or how measuring sex hormones might be useful in clinical practice.
This new study followed 1,436 men aged 65 years or older, for approximately five years. Researchers measured sex steroid levels using liquid chromatography/mass spectrometry, a highly accurate chemistry technique used for the specific detection and potential identification of chemicals in the presence of other chemicals in a complex mixture. The results of the study clearly demonstrate that estradiol and SHBG levels were most predictive of fracture risk, and men with the combination of low estradiol, low testosterone and high SHBG levels were at even higher risk for fractureâmore than three times as high as men with average levels.
Testosterone is the predominant male sex hormone and estradiol is a sex hormone that provides most estrogen effects in both men and women. SHBG, a protein that binds to estradiol and testosterone in the blood, is known to reduce circulating sex steroid concentrations and has also been associated with fracture risk.
Previous studies have shown that with aging, sex hormone concentrations decline and fracture rates increase. Until now, few studies have adequately assessed the nature of the association of sex hormones with bone fracture risk or how measuring sex hormones might be useful in clinical practice.
This new study followed 1,436 men aged 65 years or older, for approximately five years. Researchers measured sex steroid levels using liquid chromatography/mass spectrometry, a highly accurate chemistry technique used for the specific detection and potential identification of chemicals in the presence of other chemicals in a complex mixture. The results of the study clearly demonstrate that estradiol and SHBG levels were most predictive of fracture risk, and men with the combination of low estradiol, low testosterone and high SHBG levels were at even higher risk for fractureâmore than three times as high as men with average levels.
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