Severe Allergic Asthma - Cause Identified

by Rathi Manohar on  August 31, 2010 at 5:31 PM Respiratory Disease News
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The cause for severe asthma has been identified by researchers at the Cincinnati Children's Hospital Medical Center, who had used mice in their study.
 Severe Allergic Asthma - Cause Identified
Severe Allergic Asthma - Cause Identified

The disease can be triggered in susceptible people by a variety of environmental contaminants - such as cigarette smoke, allergens and airborne pollution.

Dr. Marsha Wills-Karp and her colleagues have identified the pro-inflammatory protein, interleukin-17 (IL-17A), as the molecular tipping point that upsets a delicate balance between underlying mild disease and more severe asthma, reports Nature.

Airway exposure to environmental allergens causes dysfunctional regulation of a gene called complement factor 3 (C3). This leads to overzealous production of IL-17A by airway cells and sets off what the scientists describe as an "amplification loop," when IL-17A in turn induces more C3 production at the airway surface.

The amplification loop perpetuates increasing inflammatory responses as well as airway hyper-responsiveness and airflow obstruction.

As the team continues their research, they will study the relationship between C3 and IL-17A in severe asthmatics, and explore the effectiveness of targeting either the C3 or IL-17A pathways for the treatment of severe asthma.

The study is published in the latest Nature Immunology.

Source: ANI

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