login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Scientists Uncover How Hormones Contribute to Fatty Liver
During an experiment, research leader Dr. Stephan Herzig and his colleagues switched off the cortisol receptor in the livers of mice, which led to a considerable decline in the levels of fat in the animals' livers.
Upon further investigation, the researchers observed that the experimental mice's livers started producing large amounts of a protein called HES1 in the absence of the cortisol receptor.
HES1 activates a number of enzymes that break down fat and, thus, counteract fat accumulation in the liver.
The research team say that the mice that were treated with cortisol showed a decline in HES1 levels and a rise in the accumulation of fat in their livers.
Based on their observations, the researchers came to the conclusion that the cortisol receptor acts as a switch that puts the HES1 gene off completely.
"We have discovered a key mechanism here that plays a crucial role in many pathologic metabolic disorders. It has been obvious for some time that there is an association between the body's own cortisol or therapeutically administered cortisone and the development of fatty liver. Now we also know what the interconnections look like at a molecular level," says Stephan Herzig.
This finding attains significance because fatty liver can give rise to many metabolic diseases, such as the metabolic syndrome known as "deadly quartet".
Furthermore, a combination of fatty liver, obesity, diabetes, and hypertension is regarded as the primary cause of life-threatening vascular events such as myocardial infarction and stroke.
Source-ANI
RAS/SK
|
|
More News on: Hepatitis A, Liver
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
 | Quiz on Liver Did u know that the liver is about the size of an American football? Find out more from our liver quiz. 
|
- News Quick Links
 |
Liver
Complete Medindia Resources
|
| News Categories: |
| » | Vivek Oberoi Says There is No Smoking on His Sets |
| » | Gasoigne Swaps Booze for Botox |
| » | Michelle Obama: Name of Olive Tree in Italy |
| » | Beyonce: Most Beautiful Women in the World |
| » | Robin Gibb Recovers from Coma Wakes Up to Cancer |
| More Celebrity News | |
|
