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Scientists Link Virus to Some Cases of Common Skin Cancer
The virus was first discovered in patients with Merkel cell carcinoma, a rare, aggressive skin cancer that occurs mainly in the elderly and people with a suppressed immune system.
"Originally it was thought that this virus caused only this rare skin cancer, but our findings indicate that it is a lot more prevalent than we initially thought," said principal investigator Amanda E. Toland, assistant professor of molecular virology, immunology and medical genetics and a researcher with the Ohio State University Comprehensive Cancer Centre - James Cancer Hospital and Solove Research Institute.
During the study, the researchers examined tissue samples from 58 people with squamous cell carcinoma (SCC), a highly curable form of skin cancer.
They identified the virus in more than a third of the patients and in 15 percent of the tumours tested.
In addition, all of the virus found in tumour cells had a mutation that could enable the viral DNA to integrate into the DNA of the host cell.
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