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Scientists Identify Proteins Linked to Blood Vessel Dysfunction in Diabetes
Previous studies have shown that cardiac function is compromised and cardiovascular diseases are increased in people with type 2 diabetes.
Before vascular diseases develop in diabetics, blood-vessel cell dysfunction occurs.
By identifying the proteins, the researchers hope to develop new treatments for blood-vessel dysfunction in people with type 2 diabetes.
"We believe that understanding blood-vessel dysfunction in diabetes is critical because the progression of vascular diseases may be significantly reduced if dysfunction is corrected," said Cuihua Zhang, an investigator in the Dalton Cardiovascular Research Center and associate professor of internal medicine in the MU School of Medicine.
"The results of our studies may provide new approaches for the treatment of blood-vessel diseases and disorders in type 2 diabetes, such as the possible use of antibodies that work to stop the proteins responsible for inflammation," Zhang added.
For the study, Zhang and colleagues tested their hypothesis that tumour necrosis factor-a (TNF-a), a signaling protein involved in inflammation, was responsible for blood-vessel dysfunction in type 2 diabetes.
They observed that diabetic mice had elevated levels of TNF. When diabetic mice lacked TNF, their blood vessels functioned normally.
They also observed that advanced glycation end products and their receptors (AGE/RAGE), which are proteins and lipids that are thought to contribute to various blood vessel complications, amplified TNF production in diabetes.
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