X

Scientists Identify Protein Behind Colorectal Cancer Treatment Resistance and Recurrence

by Kathy Jones on  June 11, 2011 at 9:05 PM Cancer News   - G J E 4
A -A +
A protein called ABCB5 in colorectal cancers that increases treatment resistance and recurrence of the tumour has been identified by scientists at the Children's Hospital Boston.
 Scientists Identify Protein Behind Colorectal Cancer Treatment Resistance and Recurrence
Scientists Identify Protein Behind Colorectal Cancer Treatment Resistance and Recurrence

The results indicated that eliminating ABCB5-expressing cells is crucial for successful colorectal cancer treatment.

The researchers studied ABCB5 expression in both normal and cancerous colorectal tissue specimens and discovered that it is present at levels 23 times greater in cancerous tissue than in healthy colorectal tissue.

To understand ABCB5's role in treatment resistance, the team examined biopsies gathered from colorectal cancer patients both before and after treatment with 5-fluorouracil (5-FU), a standard chemotherapeutic for this tumor.

They found that the percentage of cells expressing ABCB5 increased more than five fold after treatment.

Using a mouse model of colorectal cancer, the researchers also found that cells expressing ABCB5 were markedly resistant to 5-FU.

Knocking down ABCB5 expression both blocked the growth of these cells and restored their sensitivity to the drug, showing that ABCB5 is not only a marker of treatment resistance but actually drives it.

The study was reported online in the journal Cancer Research on June 7, 2011.

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

Most Popular News on Medindia

P
M
X

Ask an Expert

Ask an Expert+
s
Scientists Develop First Genetically Humanized Mo...
 Scientists Develop First Genetically Humanized Mouse Model for Hepatitis C
S  Brain Seizures Could be Prevented by New Drug-Loaded Electrode
Brain Seizures Could be Prevented by New Drug-Loa...