Scientists Identify Novel Therapeutic Target for Non-Hodgkin's Lymphoma

by Rajshri on  November 25, 2009 at 6:01 PM Cancer News
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The team found that Hsp90 and BCL-6 joined together within cancer cells to form a complex. They also learned that Hsp90 binds directly to the gene responsible for producing the BCL-6 protein.

Blocking Hsp90 can have a powerful effect on BCL-6 production within the cell and, therefore, tumour formation.

The experimental drug PU-H7, designed to block the activity of Hsp90, has also been found to prevent the two molecules from joining, thereby killing lymphoma cells and inhibiting new cell reproduction.

The study appears in journal Nature Medicine.

Source-ANI
RAS
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