Scientists Identify Gene That Triggers Human Cancer

by Kathy Jones on  November 12, 2010 at 9:47 PM Genetics & Stem Cells News   - G J E 4
Researchers have identified the gene responsible for initiating human cancer, thus paving the way for early cancer diagnosis.
 Scientists Identify Gene That Triggers Human Cancer
Scientists Identify Gene That Triggers Human Cancer

The study paves the way for developing early cancer diagnostic tests, and finding new treatments that prevent or stop the spread of cancer cells at an early stage.

Muy-Tek Teh of the Institute of Dentistry at Barts and the London School of Medicine and Dentistry researchers have shown that a gene called FOXM1 exploits the inherent self-renewal property of stem cells causing excessive cell proliferation.

Using adult human stem cells isolated from mouth tissues the team demonstrated that normal stem cells engineered in the lab to express abnormal levels of FOXM1 gene, triggered excessive cell growth within a 3D tissue culture model system set up to mimic human tissue regeneration in the laboratory.

The 3D tissue culture system allows scientists to perform research on manipulated human cells without provoking ethical issues associated with human or animal subjects.

Stem cells expressing normal levels of the FOXM1 gene did not cause excessive cell growth.

The abnormal growth triggered by FOXM1 resulted in a condition called hyperplasia - an early hallmark of pre-cancer. This is thought to represent the very first step of a series of abnormal molecular events leading to cancer formation.

Teh said, "Now we know that FOXM1 plays a key role in cancer initiation we aim to translate our basic findings into clinically useful molecular diagnostic tests to detect cancer growth at early stages. Furthermore, understanding the origin of cancer initiation may unveil new research opportunities for finding effective anti-tumour drugs that stop or prevent cancer at its earliest incipient stage."

The study was published in the journal Cancer Research.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All