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Scientists Identify Gene Behind Inflammatory Bowel Diseases in Kids
The findings of the study by an international team also points to a potential new target for treatment.
Co-first author of the study, Subra Kugathasan, MD, said that while scientists have earlier found several genes that influence susceptibility to the two diseases, this is the first to focus on inflammatory bowel disease (IBD) with childhood onset.
Kugathasan's future research will focus on discovery of additional IBD genes and in depth study of how these genes influence disease onset and progression.
"Our novel candidate gene is in the same inflammatory pathway as some other susceptibility genes, so it may represent an accessible target for treatment," Nature quoted Kugathasan, as saying.
Kugathasan said that both genetics and the environment have an effect on the risk of getting inflammatory bowel disease. If one identical twin suffers from Crohn's disease, the other has a 60 percent probability of getting it too.
However, he noted that the incidence of disease has drastically increased over the last half century. He also suggested a key role of the environment in disease development. Smoking is an environmental factor that is particular strong in increasing the risk of Crohn's disease.
"We have to conclude that the interactions between genetics and environment are responsible for most cases," he said.
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