A chain of molecular events that increase one's risk of sun-induced skin cancer has been identified by scientists.
The study, appearing online in The FASEB Journal, may lead to new tests that access personal skin cancer risk as well as a new generation of sunscreens that increase the skin's ability to protect itself from the sun's damaging rays.
AdvertisementZalfa A. Abdel-Malek, a researcher involved in the work from the Department of Dermatology at the University of Cincinnati, said: Our study heralds the onset of personalized medicine for individuals who carry a change in the MC1R gene.
"The data we have obtained allows us to better predict which individuals will be at risk for skin cancer, as well as potentially why and to what degree. In the future, genetic testing for MC1R gene changes may be clinically available so that individuals can be made aware of the molecular basis of their risk prior to development of cancer."
Abdel-Malek and colleagues found that when a pigmentation gene called the "melanocortin 1 receptor" or MC1R does not function properly, skin cells do not respond to a hormone, called a-MSH, which causes cells to produce dark pigmentation to protect themselves from ultraviolet rays.
To make this discovery, the researchers studied 21 human skin cell cultures that express the MC1R gene in different ways.
Each culture was studied for expression of genetic changes of MC1R, pigment levels and the ability to respond to a-MSH.
The researchers also exposed the cell cultures to ultraviolet rays and measured the amount of DNA damage and the rate of its repair, as well as the percent of surviving melanocytes.
Then the scientists inserted a normal version of the MC1R gene into the skin cells and found that they responded properly to ultraviolet light by producing the pigment necessary to protect themselves.
These results give researchers testable strategies to reduce or prevent skin cancer.
The results also suggest that it may be possible to develop drugs or a new generation of sunscreens that restore the lost function of MC1R.
Gerald Weissmann, Editor-in-Chief of The FASEB Journal, said: "This research permits us know our own, personal risk for skin cancer.
"We've known for a long time that smearing on sunscreen is the best way to avoid skin cancer, but never how much or what kind.
This study points the way to new kinds of sunscreens that restore their skin's ability to protect itself from DNA damage."
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