Scientists have identified entire networks of genes that play a key role in alcohol drinking behaviour in a study on fruit flies.
Researchers from North Carolina State and Boston universities say that this discovery provides a crucial explanation of why some people seem to tolerate alcohol better than others, as well as a potential target for drugs aimed at preventing or eliminating alcoholism.
Also, this discovery sheds new light on many of the negative side effects of drinking, such as liver damage.
"Translational studies, like this one, in which discoveries from model organisms can be applied to insights in human biology, can make us understand the balance between nature and nurture, why we behave the way we do, for better or worse, and what makes us tick," said Robert Anholt, a Professor of Biology and Genetics at North Carolina State University, Director of the W. M. Keck Center for Behavioral Biology, and one of the senior author of the study.
To make this discovery, Anholt and colleagues first measured the amount of time it took for the fruit flies to lose postural control after exposure to alcohol.
At the same time, changes in the expression of all the flies' genes were recorded.
Using statistical methods to identify genes that work together, the scientists were able to pinpoint specific genes that played a crucial role in adaptation relating to alcohol exposure.
Armed with this information about fruit flies, the scientists set out to determine if the same genes contribute to alcohol drinking habits in humans.
Indeed they do: expression of the human counterpart of a critical gene in fruit flies could be directly tied to alcohol consumption in humans, the researchers found.
The study has been published in the October 2009 print issue of the journal Genetics.