login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Scientists Have Identified the Molecules That Play Role in Bone Size
September 05, 2007 at 2:50 PM
Research News
Osteoporosis is an insidious and devastating disease that results from the loss of bone mass, which leads to fractures of the spine, the hip, and the wrist, said the senior author, Agnčs Vignery, associate professor of orthopedics.
The identification of molecules that can be targeted to prevent bone loss is therefore essential. She said that a new avenue to prevent osteoporosis and possibly, to repair bone loss, was opened by the discovery of the CD200 protein that, together with its receptor CD200R, plays a role in bone resorption by osteoclasts, the cells that remodel bone.
Osteoclasts play a central role in the development of bone. Increases in their number and/or activity lead to diseases associated with generalized bone loss, such as in osteoporosis, and diseases related to localized bone loss, such as rheumatoid arthritis and periodontal disease.
Since fusion of macrophages is a key step in creating osteoclasts, the researchers examined this molecular mechanism using genome wide DNA microarray analysis and found the expression of CD200 at the onset of the fusion. They also found that mice deficient in CD200 had fewer osteoclasts and a higher bone density, and that the soluble recombinant form of CD200R that they engineered prevented the formation of osteoclasts.
|
|
|
More News on: Infantile Cortical Hyperostosis
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
- News Quick Links
| News Categories: |
| » | Vivek Oberoi Says There is No Smoking on His Sets |
| » | Gasoigne Swaps Booze for Botox |
| » | Michelle Obama: Name of Olive Tree in Italy |
| » | Beyonce: Most Beautiful Women in the World |
| » | Robin Gibb Recovers from Coma Wakes Up to Cancer |
| More Celebrity News | |
|
