To mimic the clinical environment, they stuck to the maximum possible tobramycin dose of 1,000 micrograms per milliliter, mixed with a chelator.
The researchers found that the combination had a dramatic effect. It disrupted the mass of established and highly resistant bacteria in human airway cells by 90 percent and it also prevented formation of damaging biofilms.
In contrast, neither an iron chelator nor tobramycin alone had such success.
The study appears in the American Journal of Respiratory Cell and Molecular Biology.
Source-ANI
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