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Scientists Find Genetic Variants That Up Gynecological Disease Risk

by Kathy Jones on  December 13, 2010 at 8:14 PM Genetics & Stem Cells News   - G J E 4
Two genetic variants that increase the risk of developing endometriosis-a common gynaecological disease, have been identified by scientists.

Endometriosis is a common gynaecological disease affecting an estimated 6 to 10 per cent of all women in their reproductive years.
 Scientists Find Genetic Variants That Up Gynecological Disease Risk
Scientists Find Genetic Variants That Up Gynecological Disease Risk
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Researchers from the International Endogene Consortium compared the genomes of over 5,500 women surgically diagnosed with the disease from the UK, Australia and the US, and compared them with almost 10,000 healthy volunteers.

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They identified two new genetic variants that increase the risk of developing the disease, particularly moderate-severe stages.

"We've known for some time that endometriosis is heritable, but until now we have been unable to find any robust genetic variants that influence a woman's risk of developing the disease," said Krina Zondervan, of the University of Oxford.

The first is a variant on chromosome 7 believed to be involved in regulating nearby genes, probably those involved in the development of the womb and its lining.

The second variant was found on chromosome 1, close to the gene WNT4. This is important for hormone metabolism and the development of the female reproductive tract, especially the ovaries, making it an important biological candidate for involvement in endometriosis.

The findings were published in the journal Nature Genetics.

Source: ANI
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