Medindia

X

Scientists Find Gene That Determines Nueroblastoma Tumors

by Aruna on  June 4, 2009 at 11:04 AM Cancer News   - G J E 4
Scientists Find Gene That Determines Nueroblastoma Tumors
Virginia Commonwealth University scientists have identified a gene that may play a key role in regulating tumor progression in neuroblastoma, a form of cancer usually found in young children.
Advertisement

Lead researcher Dr Paul B. Fisher, M.Ph., from Thelma Newmeyer Corman Endowed Chair in Cancer Research has shown astrocyte elevated gene-1, AEG-1, a cancer promoting gene, is frequently activated in neuroblastoma.

Advertisement
MYCN is a known genetic determinant of neuroblastoma and elevated levels have been observed in one third of neuroblastoma patients.

The researchers found a potential correlation between AEG-1 and MYCN in neuroblastoma.

"We believe that activation of AEG-1 in addition to MYCN is critical to the development and progression of neuroblastoma," said Fisher.

"This works shows that AEG-1 plays a crucial role in the development and progression of neuroblastoma through activating important signaling pathway and induction of MYCN.

"In addition, we have shown that AEG-1 could be a potential prognostic marker for neuroblastoma and a potential target for novel therapeutic strategies for neuroblastoma patients," he added.

The team found that the elevated expression of AEG-1 makes cancer cells highly aggressive and resistant to factors that may influence cell suicide, and that loss of AEG-1 reduces the tumor-causing properties of highly aggressive neuroblastoma cells.

The study is published in the journal Oncogene.

Source: ANI
ARU
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All

More News on: