Zhang devised a method to adjust the relative intensities of short-lived blue fluorescence and long-lived yellow phosphorescence, ultimately creating a calibrated colourful glow that allows visualization of even minute levels of oxygen.
The biomaterial displays its oxygen-sensitive phosphorescence at room or body temperature, making it ideal for use in tissues.
"We have found that these nanoparticles were directly applicable to our existing tumor models," said Greg Palmer, assistant professor of radiation oncology at Duke University Medical Center.
"This technology will enable us to better characterize the influence of tumor hypoxia on tumor growth and treatment response," he added.
The study appears in journal Nature Materials.
Source-ANI
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