Scientists Craft Peptide That Turns Cancer Friend into Foe

by Rajashri on  October 9, 2008 at 2:50 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

 Scientists Craft Peptide That Turns Cancer Friend into Foe
A peptide that binds to Bcl 2, a protein that protects cancer cells from programmed cell death, and converts it into a cancer cell killer has been developed by US scientists.

The progress made by scientists at Burnham Institute for Medical Research takes then a step closer to creating new cancer treatments.

The Bcl-2 protein has long been implicated in protecting cancer cells from apoptosis, the process that usually keeps cancer cells in check.

The researchers have revealed that the peptide called NuBCP-9, and its mirror-image molecule work on Bcl-2 like a molecular switch, converting it into a pro-apoptotic protein, and inducing cell death in cancer cells.

"Our results provide insight into Bcl-2 conversion and identify a new direction for Bcl-2-based drug leads and cancer drug development," said Dr. Xiao-kun Zhang, who co-authored the paper with Dr. Arnold Satterthwait and others.

The researchers created the NuBCP-9 peptide from Nur77, a potent pro-apoptotic protein.

Nur77 often moves from the nucleus to mitochondria, in response to different death signals, where it binds to Bcl-2, changing its shape and function.

A report on this study has been published in the journal Cancer Cell.

Source: ANI
RAS/L

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Cancer and Homeopathy Cancer Facts Cancer Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive