Scientist Creates 'Designer Proteins' To Treat Heart Disease, Cancer

by Sreeraman on  June 15, 2009 at 12:55 PM General Health News
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An Indian-origin scientist at the University of Leicester has developed a new way to create "designer proteins" that could be used for drugs with potential applications in stroke, vascular inflammation, blood vessel formation, regenerative medicine, and tissue engineering.

Shikha Sharma, a member of Dr. Nick Brindle's group in the Department of Cardiovascular Sciences, revealed that the study was aimed at allowing scientists to rapidly make designer proteins that could bind to disease causing molecules in the body.

"There are millions of different proteins that are involved in carrying out numerous functions in the human body. Over time each protein has evolved to optimise its function. Disease could result if any of these fail to perform efficiently," she said.

"By generating designer proteins in test tubes, we can produce molecules that have specific actions to control processes in the body. These proteins can be used to make drugs as a treatment for heart disease and cancer.

"Whilst most drugs in current use are synthetic, these designer molecules are developed from natural proteins and are likely to have fewer side effects.

Proteins perform a well defined but complex set of function in the body and protein therapeutic drugs can perform better when compared to some synthetic small molecule drugs that may have unwanted interactions within the body.

"Current methods to generate protein therapeutic are cumbersome and time consuming. At the University of Leicester, we have developed a novel method to revolutionise the way in which we produce these designer protein drugs.

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