A safer and more efficient alternative method is used for ferrying genes of interest into cells using the new non-viral gene delivery systems using transposons
These jumping genes may provide safer and a more efficient gene delivery system.Margy Lambert, a molecular biologist and biological safety expert, has described the gene delivery potential of transposons, also known as “jumping genes”, in an article published in the journal Applied Biosafey.
The researcher says that scientists and gene therapists have to date used two proven options to move a gene from one point to another, according to the background information in the article. One of these methods involves a virus, while the other a plasmid, an engineered loop of DNA that usually delivers the genes on a short-term basis, the article adds.
Viruses can be infectious and some types of viruses occasionally land in a target genome near an oncogene and raise the risk of cancer. Plasmids, on the other hand, do not carry that risk, but they are not nearly as efficient at reproducing in cells, which is important for integrating an introduced gene into the targeted cells of the organism or patient.
Lambert says that "jumping genes" can provide a safer alternative than viruses and more efficient delivery than plasmids.
"Almost any application where you use viral vectors, you could use this technique. You can do a lot with it, and it is safer. Problems with viral vectors are extremely rare, but the consequences can be severe," says Lambert.
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Lambert revealed that in order to harness jumping genes, researchers use an enzyme to ferry a desired DNA sequence from one DNA molecule to another inside a cell. The enzyme can then be turned off to stop genes from jumping, says the expert.
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Source-ANI
SPH /J