Roughly Half of the Human Genome Made Up of Jumping Genes

by Kathy Jones on  June 27, 2010 at 1:49 PM Genetics & Stem Cells News
RSS Email Print This Page Comment
Font : A-A+

Transposons or 'jumping genes', which create genomic instability and are implicated in cancer and other diseases, make up roughly half of the human genome, geneticists have revealed.
 Roughly Half of the Human Genome Made Up of Jumping Genes
Roughly Half of the Human Genome Made Up of Jumping Genes

"Now it looks like every person might have a new insertion somewhere," says senior author Scott Devine, associate professor of medicine at the University of Maryland School of Medicine's Institute for Genome Sciences.

Transposons are like small self-replicating sequences that transfer themselves from one generation to another. But the scientists faced the overwhelming problem of finding a new insertion within three billion base pairs.

Their study indicated transposons are jumping in tumours and are generating a new kind of genomic instability. They are already known to interrupt genes and cause human diseases, including neurofibromatosis, hemophilia and breast cancer.

Scientists believe a process called methylation, which silences genes during differentiation also shuts off transposons' ability to jump. Analysing the patterns of mutations in the lung tumours suggested that during tumour formation, modified methylation patterns may be allowing transposons to re-awaken, Devine says.

The results are published in the June 25, 2010 issue of Cell.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Genetic Testing of Diseases 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive