Medindia

X

Risk of Infection is Acceptable to Most Kidney Transplant Candidates

by Rajshri on  March 26, 2010 at 8:05 PM Organ Donation News   - G J E 4
 Risk of Infection is Acceptable to Most Kidney Transplant Candidates
A study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN) says that infection is an acceptable risk for most kidney transplant candidates. It added that a majority of them are willing to receive a kidney from a donor at increased risk of viral infection.
Advertisement

The results suggest that kidney disease patients can make rational tradeoffs between the virtues and risks conferred by donated kidneys.

Advertisement
Because thousands of patients die each year in the United States while waiting for a kidney transplant, greater efforts are needed to expand the pool of kidneys for transplantation. These efforts might include allowing patients to receive less-than-ideal organs, for example from deceased individuals at increased risk of viral infection. In these cases, patients must weigh the advantages of getting a transplant against the small risk of getting a serious infection such as HIV. The average dialysis patient has a 20% chance of dying annually, similar to the death rate from metastatic cancer. Therefore patients may decide that it's better to accept an organ from a donor at increased risk of viral infection than to remain on dialysis.

Peter Reese, MD, Scott Halpern MD, PhD (University of Pennsylvania) and their colleagues conducted a study to determine what proportion of kidney transplant candidates would accept a kidney from a donor at increased risk of viral infection. They also examined what factors influenced this decision.

The investigators studied 175 kidney transplant candidates who responded to hypothetical scenarios that tested their willingness to accept a kidney from a donor at higher risk of viral infection. Each scenario varied the donor age (as a substitute for kidney quality), the risk of contracting HIV and the waiting time until the next offer of a kidney transplant. Among 175 respondents, 42 (24.0%) rejected kidneys from donors at increased risk of viral infections under all conditions, 103 (58.9%) accepted them under some conditions, and 31 (17.7%) always accepted them. Patients were more likely to accept a kidney from donors at increased risk of viral infections when the donor was younger, HIV risk was lower, and when the waiting time was longer. Also, patients on dialysis and older patients more commonly accepted such kidneys.

Increasing the use of kidneys from donors at increased risk of viral infections could improve access to kidney transplantation only if transplant candidates are willing to accept these organs. "Our study shows that the majority of kidney transplant candidates would accept the tradeoff some of the time - that is, they would accept a kidney transplant even if the risk of HIV infection was slightly elevated," said Dr. Reese.

According to the authors, transplant physicians should talk with their patients about the possibility of receiving organs from donors at increased risk of viral infections without fearing that such conversations will undermine the ability to place these organs.



Source: Eurekalert
RAS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All