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Restricted Diet from Childhood can Prolong the Human Lifespan
October 25, 2007 at 5:34 PM
Diet & Nutrition News
The research was done using a rat model of lifetime caloric restriction, and it showed that the diet reduces the amount of visceral fat, which expresses inflammatory factors that in humans cause chronic disease and a decline in physical performance and vitality across the lifespan.
'This is the first study to report that caloric restriction reduced production in visceral fat of the inflammatory cytokine IL-6 and enhanced performance on overall physical function assessments,' said Dr. Tongjian You, assistant professor of exercise and nutrition sciences in the UB School of Public Health and Health Professions and principal investigator.
'In addition, rats that ate a normal diet lost a significant amount of lean muscle mass and acquired more fat, while calorie-restricted rats maintained lean muscle mass as they aged,' he added.
The research involved male rats in three age groups—18, 24 and 29 months, comparable to ages 50-70 years in humans—which had been fed either a normal or 40-percent calorie-restricted diet from birth.
The animals were put through tests to determine grip strength, muscle tone, stamina and swimming speed.
The researchers also collected data on whole body mass, lean body mass, fat mass, percent body fat, the ratio of fat-to-lean body mass, amount of visceral fat and the amount of pro-inflammatory cytokines and C-reactive protein, a marker of chronic inflammation.
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