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Researchers Use Genetic Map To See How Staph Infections Alter Human Immune System
Infectious disease specialists at UT Southwestern Medical Center have mapped the gene profiles of children with severe S. aureus infections, to see how the pathogen alters the human immune system.
The findings of the study could open new doors for improved therapeutic interventions. It has long been unknown how the host's immune system responded to S. aureus infection, and why some individuals are more vulnerable towards severe staphylococcal infections than others.
"The beauty of our study is that we were able to use existing technology to understand in a real clinical setting what's going on in actual humans, not models, not cells, not mice, but humans. We have provided the first description of a pattern of response within an individual's immune system that is very consistent, very reproducible and very intense," said Dr. Monica Ardura, lead author of the study.
The immune system consists of two components, the innate system, which provides immediate defense against infection, and the adaptive system, whose memory cells are called into action to fight off subsequent infections.
During the study, the researchers extracted ribonucleic acid from a drop of blood, and placed it on a special gene chip called a microarray, which probes the entire human genome to determine which genes are turned on or off.
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