Researchers Identify Novel Therapy For Treating Muscular Dystrophy

by VR Sreeraman on  January 1, 2009 at 11:53 AM Research News   - G J E 4
 Researchers Identify Novel Therapy For Treating Muscular Dystrophy
Researchers at the University of Nevada School of Medicine Current have suggested that a protein, which helps cells stick together, may lead to enhanced muscle repair in muscular dystrophy.

Muscular dystrophy is a group of inherited genetic diseases that cause progressive muscle weakness.

In one type of muscular dystrophy, patients with mutations in the adhesion molecule alpha 7 integrin experience delayed developmental milestones and impaired mobility.

Currently, there is no treatment or cure for alpha 7 integrin congenital myopathy.

Interactions of alpha 7 integrin with laminin, an extracellular protein found surrounding muscle fibers, promote muscle cell health and survival.

Alpha 7 integrin has also been implicated in muscle repair.

To find out if alpha 7 integrin is critical for muscle repair, Dr. Dean Burkin at the University of Nevada and colleagues examined the response to muscle damage in alpha 7 integrin-deficient mice.

They found that alpha 7 integrin-deficient muscle exhibited defective muscular regeneration.

However, injection of laminin-111 restored muscle repair and regeneration.

The data from Rooney et al "indicate a critical role for the alpha7beta1 integrin and laminin in muscle repair and suggest direct muscle injections of laminin may serve as an exciting novel therapy for patients with alpha 7 integrin congenital myopathy and other muscle diseases."

The study appears in the January 2009 issue of The American Journal of Pathology.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

View All