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Researchers Find More Objective Way to Diagnose Obsessive Compulsive Disorder
The new way of diagnosis can also enable earlier more objective detection, and intervention.
The scientists, funded by the Medical Research Council and Wellcome Trust, have discovered that people with OCD and their close family members show under-activation of brain areas responsible for stopping habitual behaviour.
The study is published in the 18 July edition of Science.
Patients with OCD suffer from recurrent intrusive thoughts (obsessions) that are distressing and hard to suppress.
Examples include fears of contamination, or that something terrible will happen to a loved one. They also suffer from repetitive rituals (compulsions), which are often designed to neutralise these thoughts. Examples include hand-washing and checking gas hobs.
Dr Samuel Chamberlain at the University of Cambridge's Department of Psychiatry used functional magnetic resonance imaging (fMRI) to measure brain activity in the lateral orbitofrontal cortex (OFC). Located in the frontal lobes the lateral OFC is involved in decision-making and behaviour.
Volunteers were asked to look at two pictures on a screen, each image had a house and a face superimposed.
The volunteers were asked to use trial and error to work out whether the house or face was the correct target. Volunteers pressed a button to indicate which image they believed to be the target and feedback of 'correct' or 'incorrect' was given on the screen.
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