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Researchers Discover Protein That Cuts Malignancy of Breast Cancer
"This protein seems to be suppressing tumor growth," said study author Kent Hunter of the National Cancer Institute outside of Washington.
In studies on mice and in gene expression profiles of human cancer cells, Hunter and his team found that they could dramatically slow the growth of breast cancer tumors and prevent the cancer from spreading.
They did this by inserting extra copies of the gene that expresses the protein into the tumor, according to the study published in the Proceedings of the National Academy of Sciences.
While those tumors were not eliminated, they grew to one tenth of the size of those which had not been stimulated to overproduce the protein.
They also had molecular profiles of significantly less malignant tumors and did not spread.
"What were interested in is looking at how this would be induced by other means... to find a drug that would turn this gene on in tumors," Hunter said. "That would reduce the malignancy of the tumor and prolong survival."
In the meantime, the presence, or lack thereof, of this protein could be used to predict which patients are at risk of metastasis, he said.
"We could hopefully spare those patients who will not benefit the rigors associated with adjuvant therapy," he explained.
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More News on: Women and Cancer, Breast Biopsy, Pagets disease of the breast, Mastitis, Cancer and Homeopathy, Protein Catabolic Rate, Breast Cancer Facts, Cancer Facts, Cancer, Breasts - Structures and Types
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