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Researchers Discover New Molecular Path to Fight Autoimmune Diseases
March 11, 2007 at 1:27 PM
Research News
“We have uncovered a mechanism by which drugs could be developed to stabilize immune regulatory cells in order to fight autoimmune diseases,” says senior author Mark Greene, MD, PhD, the John Eckman Professor of Pathology and Laboratory Medicine. “There’s been little understanding about how the FOXP3 protein actually works.” First author Bin Li, PhD, a research associate in the Greene lab has been working on elucidating this process since FOXP3’s discovery almost five years ago.
Li discovered that the FOXP3 protein works via a complex set of enzymes. One set of those enzymes are called histone deacetylases, or HDACs. These enzymes are linked to the FOXP3 protein in association with another set of enzymes called histone acetyl transferases that modify the FOXP3 proteins.
Li found that when the histone acetyl transferases are turned on, or when the histone deacetylases are turned off, the immune regulatory cells work better and longer. As a consequence of the action of the acetylating enzyme, the FOXP3 protein functions to turn off pathways that would lead to autoimmune diseases.
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More News on: Systemic Lupus Erythematosus, Chemotherapy, Chemotherapy Drugs, Multiple Sclerosis, Myasthenia Gravis, Vitiligo, Autoimmune Disorders, Wegener’s Granulomatosis, Microscopic Polyangiitis
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guest
12/08/2007
thanks n plz let me know all news about SLE
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03/15/2007
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