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Researchers Discover Ketamine Mechanism Against Depression
However ketamine has some serious side-effects too in the short term, and so it will be a while before a new drug is developed, but meantime vitamin D supplements could help.
The Yale University stduy reported in the August 20, 2010 issue of the journal Science indicates that the findings should speed development of a safe and easy-to-administer form of the antidepressant ketamine, which is effective in treating severe depression, but needs to be delivered intravenously by medical professionals.
Ronald Duman, professor of psychiatry and pharmacology at Yale, colleagues George Aghajanian and others mapped the molecular action of ketamine in the prefrontal cortex of rats and discovered that the drug, traditionally also used as an anesthetic for children, acts on a pathway that quickly forms new synaptic connections between neurons.
Specifically, the researchers identified a critical point in the pathway, Mammalian target of rapamycin or simply mTOR, which is required to control protein synthesis for the new synaptic connections.
Still no one knows for sure when an effective like ketamine can be developed. Ketamine can cause symptoms including blurred vision, confusion, drowsiness, increased or decrease blood pressure or heart beat, metal or mood changes, nausea, vomiting and nightmares.
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