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Researchers Develop TB 'Tracker' That Helps Speed Up Drug, Vaccine Studies
The new monitoring system could speed up the slow and cumbersome process to test the safety and efficacy of various TB drug regimens and vaccines in animals.
Already, plans are under way for developing a similar system to monitor TB disease in humans.
"Worldwide there are some 9.2 million new infections with TB each year, and new drug combinations are needed fast to treat increasingly resistant strains of the bacterium. Because virtually all drugs are tested in animals first, the TB tracker will play a critical role in such preclinical studies," said senior investigator Dr. Sanjay Jain.
He added: "This new way to locate and study the disease and its behavior in animals should speed studies of TB's response to experimental vaccines, to new drugs and old ones and should accelerate our assessment of whether a treatment is working or not."
B treatment in humans and animals takes much longer than treating other bacterial infections, which makes compliance with lengthy and complicated regimens quite problematic.
In addition, some strains are already resistant to all drugs currently available, thus making it essential to find clues to how the bacterium responds to drug treatment.
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