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Research Suggests Lung Transplant Patients may Benefit from Synthetic Peptide
The study has appeared in the March issue of Critical Care Medicine.
Excess fluid and other problems that can occur within 72 hours of a transplant can significantly reduce short-term survival odds and long-term lung function. About 10 percent of patients experience an acute lung injury in the hours after their transplant, killing more than 40 percent of those patients within 30 days.
According to MCG researchers, putting the TIP peptide into the trachea of rat lungs about a half hour before transplantation can nullify the bad result, called ischemic reperfusion injury, and improve oxygenation.
Corresponding author Dr. Rudolf Lucas, vascular biologist in MCG's Vascular Biology Center, said: "We see the parameters of the transplanted lungs are nearly normal."
Reactive oxygen species are natural byproducts of oxygen use that can cause cell damage and death at high levels. Stress, such as putting dormant lungs back to work, can increase their levels.
Pointing out that donor lungs may be preserved in a cool, protective solution for several hours Dr. Lucas said: "Suddenly you put the lungs back in a body and you get an oxygen supply which by itself causes a lot of damage, mainly because of reactive oxygen species production."
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