A new research has linked a common type of chronic diarrhoea to a hormone deficiency.
Researchers from Imperial College London, with collaborators from King's College London and the University of Edinburgh, say their results could help more doctors recognise this type of diarrhoeal illness, and may lead to the development of more effective tests and treatments to help improve the lives of many people suffering with chronic diarrhoea.
AdvertisementChronic idiopathic bile acid diarrhoea occurs when an overload of bile acid reaches the colon and causes excess water to be secreted into the bowel.
The study suggests that bile acid diarrhoea is caused by the body producing too much bile acid, because of a deficiency in a hormone called FGF19, which normally switches off bile acid production.
The researchers say that new hormone-based treatments could be developed in the future to treat the condition and doctors could potentially test people's hormone levels to diagnose it.
"Bile acid diarrhoea is a common condition, likely to affect more people than Crohn's disease or ulcerative colitis, yet until now we did not understand exactly what causes it. People with bile acid diarrhoea need to use the toilet urgently many times during the day and night. This can have a big impact on their lives, at home, at work and while they are travelling, as they always need to be near a toilet," Dr Julian Walters, lead author of the study from the Division of Medicine at Imperial College London, said.
"If they are diagnosed, we have treatments that can remove bile acid from the colon, alleviate the symptoms and improve their quality of life. However, the current test used to diagnose the condition is not available in many countries and requires patients to attend the hospital twice. This means many people are not diagnosed. Our new findings mean that in the future doctors may be able to diagnose the condition by doing a quick and simple blood test," Dr Walters added.
The study has been published in the November issue of Clinical Gastroenterology and Hepatology.