Scientists can now get information about stored memories even when a person is unable or unwilling to report what they remember simply by tracking patterns of eye movements.
A new study has offered compelling insight into the relationship between activity in the hippocampus, eye movements, and both conscious and unconscious memory.
The hippocampus is a brain region that is critical for conscious recollection of past events but the precise role of this area in memory remains controversial.
According to one theory, even if explicit retrieval fails, the hippocampus might still support expressions of relational memory (e.g., memory for the co-occurrence of items in the context of some scene or event) when sensitive, indirect testing methods are used.
To test the above theory, Drs. Deborah Hannula and Charan Ranganath, both from the Center for Neuroscience at the University of California, Davis, used functional magnetic resonance imaging to examine participants' brain activity while they attempted to remember previously studied face-scene pairings.
During scanning, participants were shown a previously studied scene along with three previously studied faces and were asked to identify the face that had been paired with that scene earlier.
Eye movements were also monitored during the task and provided an indirect measure of memory.
The researchers observed that during each test trial, participants frequently spent more time viewing the face that had been previously paired with the scene-an eye-movement-based memory effect.
Surprisingly, the hippocampal activity was closely tied to participants' tendency to view the associated face, even when they failed to identify it.
They found that the activity in the prefrontal cortex, an area required for decision making, was sensitive to whether or not participants had responded correctly and communication between the prefrontal cortex and the hippocampus was increased during correct, but not incorrect, trials.
The findings may shed light on the role of the hippocampus in memory and awareness, as they suggest that even when people fail to recollect a past event, the hippocampus might still support an expression of memory through eye movements.
In addition, the results suggest that even when the hippocampus is doing its job, conscious memory may depend on interactions between the hippocampus and the prefrontal cortex.
One implication of the results is that eye movements might be used to indirectly assess memory and hippocampal function in cognitively impaired patients, children, or others who might have difficulty with conventional memory tests.
These measures might also track memory in uncooperative individuals.
"It is conceivable that eye-tracking could be used to obtain information about past events from participants who are unaware or attempting to withhold information. In other words, there may be circumstances in which eye movements provide a more robust account of past events or experiences than behavioural reports alone," said Hannula.
The study has been published in the latest issue of the journal Neuron.