A protein earlier discovered by his laboratory can inhibit the growth of breast cancer cells, an Indian-origin scientist has found.
Dr. Suresh Alahari, the Fred Brazda Professor of Biochemistry and Molecular Biology at LSU Health Sciences Center New Orleans and its Stanley S. Scott Cancer Center, earlier showed that the novel protein, Nischarin, could regulate breast cancer cell migration and movement.
The current study examined the presence and levels of Nischarin in breast cancer tumor tissue from 300 women as well as normal breast tissue samples.
"We found that normal human breast tissue samples had statistically significantly higher levels of Nischarin compared with tumor tissue samples and tumors grew significantly faster in the cells where we blocked the production of Nischarin," notes Dr. Alahari.
"Tumor growth and metastasis were also reduced in the samples where we manipulated the overproduction of Nischarin. Our research shows that Nischarin can function as a tumor suppressor of breast cancer, inhibiting breast cancer progression," he added.
The research was published online in the Journal of the National Cancer Institute.