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Research Identify Biological Pathway Behind Children's Brain Tumour
Working on behalf of the Children's Cancer and Leukaemia Group (CCLG), the researchers have found that the WNT biological pathway is "activated" in over one-third of the cases of central nervous system primitive neuroectodermal tumours (CNS PNET).
The researchers say that their study also highlighted a link between WNT pathway activation and patient survival, for those having a CNS PNET tumour that was activated survived for longer than those without pathway activation.he researchers admit the fact that the reason for the link between WNT pathway activation and better patient prognosis is as yet unclear, but believe that it could be that these tumours represent a less aggressive subset or that pathway activation itself actually harms the tumour.
According to them, the pathway could represent an important new target for the treatment of more effective drugs, with fewer side effects.
"The principal aim of our research is to reduce the morbidity and mortality of children with central nervous system tumours through improved understanding of tumour biology. Following on from this, we need to translate this knowledge into effective new treatments for brain tumours through the development and assessment of accurately targeted treatments that will cause fewer side effects than conventional chemotherapy or radiotherapy and be more effective," said senior author Professor Richard Grundy, from the Children's Brain Tumour Research Centre.
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More News on: Parkinsons Disease, Parkinsons Disease Surgical Treatment, Cysts and Tumours, Brain, Tumor Markers For Cancer Diagnosis and Prognosis, Brain Facts, Ataxia
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