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Research Finds Restrictions on Female Plasma may Not be Warranted
The Duke team conducted a retrospective study of Red Cross donor and hospital data from a period when female plasma wasn't restricted. They examined heart surgery outcomes for lung problems, and prolonged length of hospital stay or death. Cardiac surgery patients use about one-fifth of all transfused blood products.
They found that patients receiving female-donor plasma did significantly better than similar patients receiving male-donor plasma.
"Our findings raise the possibility of unanticipated effects of restricting female donor plasma use," said Mark Stafford-Smith, M.D., a Duke professor of anesthesiology and senior author of a study appearing in the Journal of Thoracic and Cardiovascular Surgery on Feb. 11.
Blood products, such as red cells and plasma, are manufactured from blood collected from volunteer donors, and both male and female donors are still encouraged to donate whole blood, which is then separated into different components.
The recommendations to restrict plasma transfusions were based on evidence tying female-donor plasma to a serious lung injury called transfusion-related acute lung injury (TRALI). Antibodies that may cause TRALI are more common in women who have been pregnant, and the antibodies may form as a reaction to their fetus. The more pregnancies a woman has had, the greater the chance that she has these antibodies.
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