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Remote Controlled Nanoparticles Answer to Drug Delivery in Cancer

by Medindia Content Team on  November 19, 2007 at 6:06 PM Cancer News   - G J E 4
Remote Controlled Nanoparticles Answer to Drug Delivery in Cancer
Nanoparticles operated by remote control have been devised by scientists that release anti-tumour drugs when pulsed with an electromagnetic field. This novel targeted treatment of cancer, reported in the November 15 online issue of Advanced Materials, could improve diagnosis and treatment.
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In earlier work the team, led by Sangeeta Bhatia, M.D.,Ph.D., an associate professor in the Harvard-MIT Division of Health Sciences & Technology (HST) and in MIT's Department of Electrical Engineering and Computer Science, developed injectable multi-functional nanoparticles designed to flow through the bloodstream, home to tumors and clump together. Clumped particles help clinicians visualize tumors through magnetic resonance imaging (MRI).

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With the ability to see the clumped particles, Bhatia's co-author in the current work, Geoff von Maltzahn, asked the next question: "Can we talk back to them?"

The answer is yes, the team found. The system that makes it possible consists of tiny particles (billionths of a meter in size) that are superparamagnetic, a property that causes them to give off heat when they are exposed to a magnetic field. Tethered to these particles are active molecules, such as therapeutic drugs.

Exposing the particles to a low-frequency electromagnetic field causes the particles to radiate heat that, in turn, melts the tethers and releases the drugs. The waves in this magnetic field have frequencies between 350 and 400 kilohertz—the same range as radio waves. These waves pass harmlessly through the body and heat only the nanoparticles. For comparison, microwaves, which will cook tissue, have frequencies measured in gigahertz, or about a million times more powerful.

The tethers in the system consist of strands of DNA, "a classical heat sensitive material," said von Maltzahn, a graduate student in HST. Two strands of DNA link together through hydrogen bonds that break when heated. In the presence of the magnetic field, heat generated by the nanoparticles breaks these, leaving one strand attached to the particle and allowing the other to float away with its cargo.

One advantage of a DNA tether is that its melting point is tunable. Longer strands and differently coded strands require different amounts of heat to break. This heat-sensitive tuneability makes it possible for a single particle to simultaneously carry many different types of cargo, each of which can be released at different times or in various combinations by applying different frequencies or durations of electromagnetic pulses.

To test the particles, the researchers implanted mice with a tumor-like gel saturated with nanoparticles. They placed the implanted mouse into the well of a cup-shaped electrical coil and activated the magnetic pulse. The results confirm that without the pulse, the tethers remain unbroken. With the pulse, the tethers break and release the drugs into the surrounding tissue.

The experiment is a proof of principal demonstrating a safe and effective means of tunable remote activation. However, work remains to be done before such therapies become viable in the clinic.

To heat the region, for example, a critical mass of injected particles must clump together inside the tumor. The team is still working to make intravenously injected particles clump effectively enough to achieve this critical mass.

"Our overall goal is to create multifunctional nanoparticles that home to a tumor, accumulate, and provide customizable remotely activated drug delivery right at the site of the disease," said Bhatia.



Source: Eurekalert
KAR/P
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All of or any DISEASE, at large is but either a Symptom and/or an Effect as a product' Inherency been a manifestation {predisposiveness] of its own innate & intrinsic source at quantum level of an Extant as a beingness which is termed to be called and known as a CAUSE. All of Cosmos & Nature, both, works on a Uni-principle of Cause & Effect Continuum. So is the Disease ... as a minion-part of being a Nature'Product.

In this 'Quantum World Of Beingness' ... in the Cellular existence of Humankind, the allied and varied, but distinctive Extants are in pleroma & plerosis (fulness) to create all of GENOME, not only the genes (1 lac) unto neuclosomes (30 millions) and neuclotides ( 3 to 4 billions)... But much beyond at an imponderable state of Piezophotonics where Photons & Positrons are at Work... ; in the subtlety of Quantum-myriad unto the exquistie Permutation & Combination of TITHONS, which are the building constituents for all of Quantum Beingness. These TITHONs rules the Orderliness of the NEURONS unto the NEURO-TRANSMITTERs to enable their catering of 'Cosmic Efficacy & Tithonicity', building an inherency and intrinsicity of the QUALITATIVITY of A Beingness of a particular Being. Corroboratively, the entire delves, lucubrations and empiric processes have to be attuned and aligned before we can find a Positive Call to treat & heal ~ both, as a redressals to have a supplementary answer to All of or any Disease.

This path is to be acertained in the domain of ASTRAL SCIENCE by the process of a Theory called "Cosmic Efficacy & Tithonicity" as an unique answer and an ELIXIR to Humankind.

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CHARANJEET SINGH LAMBA ... [ gnosiologist : exegete : astral scientist ]
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guest Tuesday, September 2, 2008
19th Nov'07. Sir/Madam, Need to explicate and communicate through my self delve written ARTICLES (Theory) on ASTRAL-SCIENCE in due context to Para-Physics and Omnijecrtivism, a detalied study of/for HUMAN-SCIENCE, as to how Colours ; the component of Light, as vibrational medicine effects and affects the bio'entity as a Quantum Energy playing softer but dynamic hands in domain of sub-nuclear world, beyond genes : nucleosome : haplotypes : nucleotides, indeed in Quantum-field of Cellular indepths much before the origin of even PHOTONS {Photons : which is been declared as the principal-carrier of ENERGY ; ELECTROMAGNETIC PHENOMENA OF ALL SEVEN RAYS} " To know the unknown is Knowledge, but to Re-know the known is also knowledge (in its refinity)" " Its better to be the Refugee of others Intellect than to be prisioners of our own Knowledge" Thanks, await to have a valued words of Considerations REGARDS & GREETINGS
guest Monday, November 19, 2007

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