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Relationship of Oral Cancers and Periodontal Disease Studied

by Kathy Jones on July 15, 2010 at 10:48 PM Dental News

J. Meyle, Justus Liebig University, Giessen, Germany, will present an abstract titled "P. gingivalis Infection and Immune Evasion of Oral Carcinomas" at the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain

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Meyle and his team are investigating the relationship of oral cancers and periodontal disease. They achieved results by infecting cell carcinoma cells SCC-25 with Porphyromonas gingivalis (P.g.) W83. After 48h the cells were stained with antibodies against human B7-H1, B7-DC and TLR4 and analysed by flow cytometry. RNA was extracted after 24h and gene expression of B7-H1, B7DC, TLR4, IFN-γ and IL-10 was quantified by real time PCR and analysed by the ΔΔCT method.

Up-regulation of B7-H1 in host cells may contribute to the chronicity of inflammatory disorders which frequently precede the development of human cancers. B7-H1 expression was detected in the majority of human cancers and leads to anergy and apoptosis of activated T cells, which might enable tumors to evade the immune response. TLR4 signalling has been shown to induce B7-H1 in bladder cancer cells.

P.g., a putative periodontal pathogen, is an etiologic agent of periodontitis and expresses a variety of virulence factors. In this study the expression of B7-H1 and B7-DC receptors and TLR4 on squamous cell carcinoma cells SCC-25 was analysed after infection with P.g. in vitro.

The research concludes that P.g. is able to induce the expression of the immune regulating receptors B7-H1 and B7-DC in squamous cell carcinoma which may facilitate immune evasion of oral cancers in patients with periodontal infections.

Source-Eurekalert

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Relationship of Oral Cancers and Periodontal Disease Studied

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