Rectal Gel Prevents HIV Transmission in Monkeys: Study

by VR Sreeraman on  August 6, 2008 at 6:25 PM Drug News   - G J E 4
 Rectal Gel Prevents HIV Transmission in Monkeys: Study
A new study suggests that the HIV drug tenofovir may prevent AIDS transmission when applied rectally as a gel.

Martin Cranage of St. George''s University of London and colleagues conducted a study of macaques that were challenged with a potent monkey AIDS virus (SIV) administered rectally.

The researchers found that most of the macaques pre-treated with rectal tenofovir gel up to 2 hours before the viral challenge were partly or totally protected from SIV infection.

Animals that were untreated or treated with a placebo gel became infected with SIV.

Some of the protected macaques were also found to developed T-cell immune responses to the virus.

The researchers say that their findings suggest that topical treatment with antiretroviral drugs before exposure might be used to prevent rectal HIV transmission in people.

They, however, concede that efficacy cannot be shown conclusively in animal studies.

They also revealed that human trials of a potential vaginal microbicide that worked well in macaques were halted recently because women using the microbicide showed increased rates of HIV infection.

Given that HIV targets activated T cells, the researchers are of the opinion that experiments should be conducted to check that the observed immune responses do not increase the likelihood of infection on later exposure before this approach can be tested in humans.

The study has been published in the journal PLoS Medicine.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions
this info* Your Email address will not be displayed or misused
Once you edit and submit - your comments will automatically get posted on medindia. However be reminded that all comments are reviewed and if they do not conform to medindia's privacy policy they will be deleted.

Please do not abuse this section by adding promotional material; also avoid adding your email, telephone numbers or website address.

This section often has questions asked by a member and if you are genuinely interested in helping them you are welcome to respond, but our request is not to mislead a vulnerable person who is in need of help.
rmation is very good.

guest Thursday, August 7, 2008

You May Also Like

View All