A missing link which explains brain state and the neural triggers accountable for learning have been uncovered by scientists from the University of Bristol.
The discovery opens up new ways of boosting cognitive function in the face of diseases such as Alzheimer's as well as enhancing memory in healthy people.
Much is known about the neural processes that occur during learning but until now it has not been clear why it occurs during certain brain states but not others.
Now researchers have been able to study, in isolation, the specific neurotransmitter, which enhances learning and memory.
Acetylcholine is released in the brain during learning and is critical for the acquisition of new memories. Its role is to facilitate the activity of NMDA receptors, proteins that control the strength of connections between nerve cells in the brain.
Currently, the only effective treatment for the symptoms of cognitive impairment seen in diseases such as Alzheimer's is through the use of drugs that boost the amount of acetylcholine release and thereby enhance cognitive function.
Researchers have shown that acetylcholine facilitates NMDA receptors by inhibiting the activity of other proteins called SK channels whose normal role is to restrict the activity of NMDA receptors.
This discovery of a role for SK channels provides new insight into the mechanisms underlying learning and memory. SK channels normally act as a barrier to NMDA receptor function, inhibiting changes in the strength of connections between nerve cells and therefore restricting the brain's ability to encode memories.
Findings from this latest research show that the SK channel barrier can be removed by the release of acetylcholine in the brain in order to enhance our ability to learn and remember information.
"These findings are not going to revolutionise the treatment of Alzheimer's disease or other forms of cognitive impairment overnight. However, national and international funding bodies have recently made research into aging and dementia a top priority so we expect many more advances in our understanding of the mechanisms underlying learning and memory in both health and disease," lead researcher Dr Jack Mellor, from the University of Bristol's Medical School, said.
The team studied the effects of drugs that target acetylcholine receptors and SK channels on the strength of connections between nerve cells in animal brain tissue.
They found that changes in connection strength were facilitated by the presence of drugs that activate acetylcholine receptors or block SK channels revealing the link between the two proteins.
The study has been described in the journal Neuron.