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Rabies in Mice Reversed After Just One Injection by New Vaccine
The team of American virologists and immunologists, who have engineered the new strain of the rabies virus, say that it induces a far more potent immune response than current vaccines.
They have revealed that in mice already infected with a virulent rabies strain, a single administration of the new vaccine was enough to clear the virus from the body, even after early symptoms had appeared.
The finding attains significance considering that conventional post-exposure rabies vaccines require several injections to produce an appropriate immune response.
Virologist Bernhard Dietzschold and his team at Thomas Jefferson University in Philadelphia, Pennsylvania, say that they wanted to make the new virus strain as safe as an inactivated virus, yet able to rouse the immune response to expunge the infecting virus as quickly as possible.
To make sure the viral strain they developed did not cause disease, they injected it directly into the brains of healthy, but very young, mice.
Pups as young as five days old did not show any signs of rabies.
"This means it's a lot safer than other live attenuated vaccines that are out there," Nature magazine quoted study co-author Craig Hooper, also at Thomas Jefferson, as saying.
Dietzschold and his co-workers then infected adult mice with a virulent strain of rabies virus, injecting the pathogen either into muscle or directly into the brain, and found that their new vaccine could prevent onset of the disease if it was administered within three days of exposure.
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