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Protein That Monitors Blood Vessel Growth Identified
December 05, 2007 at 6:15 PM
Research News
Upon injury, the body grows new blood vessels to repair damaged tissue. However, too much growth may sometimes cause problemslike when new blood vessels in the eyes leak and are not treated, they may cause diabetic retinopathy and blindness.
Researchers at the University of North Carolina at Chapel Hill School have now found in a study that the CIB1 protein appears to control new blood vessel growth.
The new finding attains significance as it offers a target for drug treatments to help the body repair itself after injury and control unwanted blood vessel growth.
In the future, this knowledge may help our ability to control blood vessel growth in disease situations such as wound healing, retinal diseases and diabetes, said Dr. Leslie Parise, senior study author and professor and chair of biochemistry and biophysics in the UNC School of Medicine.
During the study, funded by the National Institutes of Health, Parises team CIB1 in the endothelial cells that line all blood vessels.
According to the background information, these cells jump-start new blood vessel growth via a process called angiogenesis, during which biological signals prompt endothelial cells to release enzymes and other chemicals that allow them to move away from existing blood vessels and form new ones.
The researchers say that while angiogenesis plays a critical role in embryo growth, CIB1 appears to only affect blood vessel growth after injury.
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