A protein that regulates forgetting of short-term memories, such as a new phone number or the name of a new acquaintance, has been identified by scientists.
A research team led by a scientist at Cold Spring Harbor Laboratory (CSHL) has found that forgetting of short-term memory is regulated within neurons by the activity of a protein called Rac.
Naturally occurring Rac activation within neurons located in a fruit fly organ called the mushroom body was linked experimentally with three distinct memory-erasure tasks by CSHL Professor Yi Zhong and colleagues at Tsinghua University in Beijing.
One kind of erasure is associated with gradual short-term memory loss; another entails an acute, rapid removal of short-term memory; a third involves a kind of erasure associated with new information that interferes with an existing short-term memory.
In all three kinds of erasure, the team has found, the process of forgetting is mediated by a mechanism dependent upon the activity level of Rac, a protein that belongs to the Rho family of GTPases. These are a type of protein known to act, among other things, as regulators of the cytoskeleton, the superstructure of cells.
Importantly, Zhong and colleagues propose that Rac's role in erasing memory is directly related to its function as a cytoskeleton remodeling agent. In genetically modified flies, the team elevated Rac activity in mushroom body neurons, which are the seat of olfactory-based memories in the fly.
Elevated Rac activity had the effect of accelerating the decay of short-term memories. The process worked in the other direction, too. By inhibiting the activity of Rac they observed that short-term memories decayed more slowly than normal, lasting more than a full day rather than vanishing within three hours, as they do, on average, when Rac is not blocked.
The scientists reported that the Rac-dependent forgetting mechanism in flies did not affect mechanisms involved in the formation of new memories, specifically a pathway associated with the gene Rutabaga that is mediated by the enzyme adenylyl cyclase.
"The molecular basis of short-term memory really has been overlooked by the neuroscience community. It has been widely assumed that such memory is degraded through passive cellular processes. Our experiments challenge the notion by providing evidence of a dedicated mechanism for removing several kinds of short-term memories," Zhong said.
The results will be published online ahead of print February 19 in the journal Cell.