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Protein Crucial To Bone Strength Identified
A developing mouse with neogenin deficits has poorly defined digits and is generally smaller, including having small growth plates, an indicator of future development, said Dr. Wen-Cheng Xiong, developmental neurobiologist in the Schools of Medicine and Graduate Studies, Medical College of Georgia. He is the corresponding author of the study published in Developmental Cell. Dr. Zheng Zhou, MCG assistant research scientist, is first author.
Their findings provide new insight into skeletal development as they point toward a potential new direction for treating osteoarthritis, a common, painful and debilitating condition where cartilage between bones is lost, Xiong said.
Neogenin doesnt make bone; rather, it forms a protein complex essential to turning on cartilage-producing genes, the researchers found. Each cell type has a master gene. Neogenin is not that, its more of a modulator, Xiong said. Thats why, if its mutated, like in the mouse, cartilage and bone formation is disrupted not halted. Its also why neogenin could be a good therapeutic target for turning the tide on cartilage or bone loss that occurs in osteoarthritis, Xiong said.
Skeletal development occurs early, which is why pregnant women need so much calcium. Initially the skeleton consists of soft bone or cartilage, which attracts blood vessels as well as the osteoblasts that replace most cartilage with hard bone over time. After birth, growth plates, where hard and soft bone meet, enable bones to lengthen and children to grow. After puberty, growth plates go away and bone hardens except for cartilage at the joints that eases movement and provides cushion. While bone cells continue to turn over, bone growth and loss should balance each other out after puberty due to osteoclasts cells that break down and resorb bone. Diseases such as osteoporosis and osteoarthritis occur when osteoclasts start winning. Nutrition, inflammation and hormones are among the many factors that impact bones status.
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More News on: Infantile Cortical Hyperostosis, Protein Catabolic Rate
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