Protein Bcl-xL Prevents Bone Breakdown

by Rajashri on  September 16, 2009 at 10:09 PM Research News
RSS Email Print This Page Comment
 Protein Bcl-xL Prevents Bone Breakdown
While the protein Bcl-xL has a well-characterized role in preventing cell death by a process known as apoptosis, its function in osteoclasts, cells that slowly breakdown bone has not been determined.

In addressing this issue, Sakae Tanaka and colleagues, at The University of Tokyo, Japan, have discovered that not only does Bcl-xL prevent osteoclast apoptosis in mice, it also negatively regulates the bone-resorbing activity of osteoclasts.

To determine the function of Bcl-xL in osteoclasts, the researchers generated mice lacking Bcl-xL only in osteoclasts. As in blood cells, Bcl-xL was shown to promote the survival of osteoclasts. Unexpectedly, however, the mutant mice exhibited marked osteopenia at one year of age. Further analysis indicated that the reduced bone mass was caused by increased osteoclast-mediated bone resorption and identified a potential underlying mechanism. Specifically, Bcl-xL was found to decrease the production of extracellular matrix proteins, which bind cell surface integrin molecules, leading to the activation of c-Src signaling pathways that are already known to promote osteoclast-mediated bone resorption. Thus, in the absence of Bcl-xL, increased production of extracellular matrix proteins leads to increased osteoclast-mediated bone resorption.



Source: Eurekalert
RAS

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
* Your comment can be maximum of 2500 characters
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Infantile Cortical Hyperostosis Diet and Nutrition Tips for Athletes Renal Osteodystrophy / Mineral Bone Disorder 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.


Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive