Medindia

X

Protein Atf4 Found to Regulate Bone-cell Control of Energy Generation

by Rajashri on  August 12, 2009 at 9:57 PM Research News   - G J E 4
 Protein Atf4 Found to Regulate Bone-cell Control of Energy Generation
It has come to light very recently that bone cells known as osteoblasts have a role in controlling the biochemical reactions that generate energy via secretion of the molecule osteocalcin.
Advertisement

Gerard Karsenty and colleagues, at Columbia University College of Physicians and Surgeons, New York, therefore hypothesized that osteoblasts express a regulatory gene(s) that controls this osteoblast function and then identified Atf4 as this regulatory gene in mice.

Advertisement
Atf4 is a protein expressed predominantly in osteoblasts that is known to regulate many osteoblast functions. The researchers therefore analyzed mice lacking Atf4 and found that they have lower fat mass and blood glucose (a major source of energy) levels than control mice. The lower blood glucose levels were due to increased expression and secretion of the hormone insulin, which promotes liver, fat, and muscle cells to take up glucose. Sensitivity to insulin in the liver, fat, and muscle was also enhanced. Several genetic experiments established that lack of Atf4 in osteoblasts was central to these abnormal characteristics of mice lacking Atf4 and further analysis indicated the underlying mechanism. Specifically, Atf4 directly increased expression of the Esp gene, which makes a protein that decreases the activity of osteocalcin. As Atf4 in osteoblasts was already known to regulate bone formation and mineralization, the authors conclude that Atf4 regulates many, but not all, osteoblast functions.



Source: Eurekalert
RAS
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All